Numerous police vehicles, along with paramedics, are present at the scene according to eyewitnesses. There are also reports of an injured pedestrian being treated by the North West Ambulance Service close to the Tollgate pub.
It comes as thousands of football fans have been leaving the nearby football stadium following the Manchester United v Bournemouth match tonight.
Talbot Road was being used by diverted buses before and after the match but has since been blocked by police following the incident.